Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/269422814?client_source=feed&format=rss
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4 hrs.
Devin Coldewey , NBC News
An "artificial eye" is still a long ways off, but researchers have made the low-resolution devices now available useful in a new way.?Instead of trying to replace vision entirely, they only "translate" text, presenting it to the user in a more familiar format: Braille.
Today's retinal implants are promising and allow people suffering from certain kinds of visual disability to see very rough shapes and contrasts. But with a resolution of only a few hundred total pixels, they are unable to display the world in anything but the lowest fidelity.
But replicating vision isn't just about the view. Sighted people take the ability to read things like?street signs and menus for granted, but not only is this difficult or impossible for most visually-impaired?people, there are relatively few accommodations available, as there are for things like crossing the street or using an ATM.
With this in mind, the team at Second Sight decided to modify?an Argus II retinal implant system, in which visual signals are presented to the retina in the form of electrical signals. They hooked the built-in camera up to software that translates text it sees into Braille, and then sent that signal on to be displayed by the implanted electrode arrays.
Low resolution isn't a problem for Braille, since letters are represented as dots in a three-by-two grid rather than using the lines and curves of standard glyphography. In testing, they would show up to four letters at a time ? not efficient for reading longer sentences, but?enough to quickly differentiate between "left" and "right," "open" and "closed," or "men" and "women."
Their test subject?had limited success with the system: Already a user of Braille and the Argus II implant, he was able to identify letters correctly 89 percent of the time. But as the length of the word grew, success rate fell.
Still, any improvement over the previous system, in which the highly pixelated image could barely show letters or words at all, would surely be welcome to users of the implant. While for reading books and articles, Braille is much faster, that option doesn't exist for many signs and other pieces of writing.
At the moment, retinal implants are still something of a rarity; while hundreds of thousands could potentially benefit from the technology, they are still in a relatively early stage of development and have not yet entered widespread clinical testing. But whenever they start to be prescribed to the general population, having helpful alternative modes like this one could be very important to the people for whom they are intended.
The paper describing the research, "Reading visual braille with a retinal prosthesis," appeared recently?in "Frontiers in Neuroprosthetics." The lead author is?Thomas Lauritzen of Second Sight, in collaboration with colleagues from?Brigham Young University and two French vision research institutes.
Devin Coldewey is a contributing writer for NBC?News Digital. His personal website is?coldewey.cc.
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Walmart protests on Black Friday by some employees are an attempt to shame the company into public action ? even though the workers are not organized into a labor union. Extent of Walmart protests still unclear.
By Mark Guarino,?Staff writer / November 23, 2012
EnlargeIn staging nationwide protests at Wal-Mart stores on Black Friday, employees and labor unions are turning back the clock ? trying to influence America?s largest retailer in ways that were the norm before the union movement started in the 1930s.
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The disgruntled employees group organizing Friday?s walkouts, called Organization United for Respect at Walmart (OUR Walmart), complains that Wal-Mart pays low wages and sets unfair labor conditions. But since Wal-Mart employees are not organized into a union, they can?t strike to air their grievances.
Instead, the Black Friday protests are only the latest ? and most ambitious ??of a series of attempts by OUR Walmart and others to publicly shame the company into listening to grievances.
?What is making today so interesting, and what this Walmart group has found, is there may be a way to essentially change Walmart?s behavior legally without having to actually organize 51 percent of the workers,? says Robert Bruno, director of the Labor Education Program at the University of Illinois in Chicago. ?While I?m sure that [union organizing] is still the objective, in the meantime they can create a lot of rights using less workers and without having to represent them.?
Wal-Mart officials say disgruntled workers make up far less than the 51 percent of the workforce needed to organize a union according to federal law. Moreover, they say that the United Food and Commercial Workers International Union, which is supporting OUR Walmart, is illegally interfering in the company?s business. The company filed a complaint with the National Labor Relations Board last Friday.
It is unclear how many protests are taking place, though local media reports show they are spread nationwide. They have been relatively peaceful, according to reports. OUR Walmart says that protests are being held at 1,000 stores in the US, but Wal-Mart calls that number ?grossly exaggerated,? according to a statement by spokesman David Tovar.
It says that many of the people in the protests are not employees at all. The company estimates that ?less than 50 associates participated in the protest nationwide ? roughly the same number of associates missed their scheduled shifts as last year,? said Bill Simon, Wal-Mart?s US president and chief executive officer, in a statement.
In Milwaukee, about 60 protesters arrived in buses at two separate Wal-Mart locations, where they marched around each building, holding signs and chanting. Several hundred protesters organized outside a Wal-Mart store in Capitol Plaza in Landover Hills, Md., outside Washington, according to a local CBS station. In Orlando, Fla., US Rep.-elect Alan Grayson (D) joined protesters.
Professor Bruno says it is inevitable that the labor movement would target Wal-Mart, because the firm has emerged to play such an important role in the new economy.
?Wal-Mart is GM and US Steel amplified. They are a key employer in a large industry that, given the changes in our economy, has become more important than they might have been several years ago,? he says. The Black Friday protests are a ?product of a series of experimental efforts over years to organize Wal-Mart and to recognize and improve the working conditions there.?
Since September, OUR Walmart has staged protests at company stores, hoping to force the company to pay an hourly minimum wage of $13, make full-time jobs a priority for existing employees, provide affordable health care, and more. The group also says Wal-Mart has unfairly retaliated against certain employees for various reasons, from needing to change work schedules to speaking out against the company.
Wal-Mart workers currently must work an average of 30 hours per week to receive benefits, and the average full-time hourly wage is $12.57, according to the company website.
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Collier on Bankruptcy was cited in this recent decision:
Collier on Bankruptcy section cited: 1 Collier on Bankruptcy ? 3.05?(accessible by lexis.com subscribers)
Lexis.com subscribers can view the enhanced version of Power Plant Entm?t Casino Resort Ind., LLC v. Mangano.
Lexis.com Overview: The removing defendants raised the argument that possible rulings in the state court action could have collateral estoppel effect on the debtor, precluding the debtor from relitigating such matters in any potential proceeding regarding indemnification in the bankruptcy court. The bankruptcy court found?.?
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Scientists at Disney's research labs in Zurich, Switzerland, recently unveiled their newest technique for making animatronics more life-like: cloning an actual human face. By using motion capture technology, scientists can make a three-dimensional scan of a person's face as the subject runs through various facial expressions like yawning and winking. They then catalog every detail of that person's face?from facial hair to freckles?into a digital 3D rendering. That rendering is used to craft a precise skin replica by injecting liquid silicone into a 3D mold and allowing it to cure. This ?mask' adheres to a motorized metal and plastic skull outfitted with points that show exactly where the skin should be placed.
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Contact: Srinivas Aluru
aluru@iastate.edu
515-294-3539
Iowa State University
AMES, Iowa Today's life scientists are producing genomes galore.
But there's a problem: The latest DNA sequencing instruments are burying researchers in trillions of bytes of data and overwhelming existing tools in biological computing. It doesn't help that there's a variety of sequencing instruments feeding a diverse set of applications.
Iowa State University's Srinivas Aluru is leading a research team that's developing a set of solutions using high performance computing. The researchers want to develop core techniques, parallel algorithms and software libraries to help researchers adapt parallel computing techniques to high-throughput DNA sequencing, the next generation of sequencing technologies.
Those technologies are now ubiquitous, "enabling single investigators with limited budgets to carry out what could only be accomplished by an international network of major sequencing centers just a decade ago," said Aluru, the Ross Martin Mehl and Marylyne Munas Mehl Professor of Computer Engineering at Iowa State.
"Seven years ago we were able to sequence DNA one fragment at a time," he said. "Now researchers can read up to 6 billion DNA sequences in one experiment.
"How do we address these big data issues?"
A three-year, $2 million grant from the BIGDATA program of the National Science Foundation and the National Institutes of Health will support the search for a solution by Aluru and researchers from Iowa State, Stanford University, Virginia Tech and the University of Michigan. In addition to Aluru, the project's leaders at Iowa State are Patrick Schnable, Iowa State's Baker Professor of Agronomy and director of the centers for Plant Genomics and Carbon Capturing Crops, and Jaroslaw Zola, a former research assistant professor in electrical and computer engineering who recently moved to Rutgers University.
The majority of the grant $1.3 million will support research at Iowa State. And Aluru is quick to say that none of the grant will support hardware development.
Researchers will start by identifying a large set of building blocks frequently used in genomic studies. They'll develop the parallel algorithms and high performance implementations needed to do the necessary data analysis. And they'll wrap all of those technologies in software libraries researchers can access for help. On top of all that, they'll design a domain specific language that automatically generates computing codes for researchers.
Aluru said that should be much more effective than asking high performance computing specialists to develop parallel approaches to each and every application.
"The goal is to empower the broader community to benefit from clever parallel algorithms, highly tuned implementations and specialized high performance computing hardware, without requiring expertise in any of these," says a summary of the research project.
Aluru said the resulting software libraries will be fully open-sourced. Researchers will be free to use the libraries while developing, editing and modifying them as needed.
"We're hoping this approach can be the most cost-effective and fastest way to gain adoption in the research community," Aluru said. "We want to get everybody up to speed using high performance computing."
###
Contacts:
Srinivas Aluru, Electrical and Computer Engineering, 515-294-3539, aluru@iastate.edu
Mike Krapfl, News Service, 515-294-4917, mkrapfl@iastate.edu
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Srinivas Aluru
aluru@iastate.edu
515-294-3539
Iowa State University
AMES, Iowa Today's life scientists are producing genomes galore.
But there's a problem: The latest DNA sequencing instruments are burying researchers in trillions of bytes of data and overwhelming existing tools in biological computing. It doesn't help that there's a variety of sequencing instruments feeding a diverse set of applications.
Iowa State University's Srinivas Aluru is leading a research team that's developing a set of solutions using high performance computing. The researchers want to develop core techniques, parallel algorithms and software libraries to help researchers adapt parallel computing techniques to high-throughput DNA sequencing, the next generation of sequencing technologies.
Those technologies are now ubiquitous, "enabling single investigators with limited budgets to carry out what could only be accomplished by an international network of major sequencing centers just a decade ago," said Aluru, the Ross Martin Mehl and Marylyne Munas Mehl Professor of Computer Engineering at Iowa State.
"Seven years ago we were able to sequence DNA one fragment at a time," he said. "Now researchers can read up to 6 billion DNA sequences in one experiment.
"How do we address these big data issues?"
A three-year, $2 million grant from the BIGDATA program of the National Science Foundation and the National Institutes of Health will support the search for a solution by Aluru and researchers from Iowa State, Stanford University, Virginia Tech and the University of Michigan. In addition to Aluru, the project's leaders at Iowa State are Patrick Schnable, Iowa State's Baker Professor of Agronomy and director of the centers for Plant Genomics and Carbon Capturing Crops, and Jaroslaw Zola, a former research assistant professor in electrical and computer engineering who recently moved to Rutgers University.
The majority of the grant $1.3 million will support research at Iowa State. And Aluru is quick to say that none of the grant will support hardware development.
Researchers will start by identifying a large set of building blocks frequently used in genomic studies. They'll develop the parallel algorithms and high performance implementations needed to do the necessary data analysis. And they'll wrap all of those technologies in software libraries researchers can access for help. On top of all that, they'll design a domain specific language that automatically generates computing codes for researchers.
Aluru said that should be much more effective than asking high performance computing specialists to develop parallel approaches to each and every application.
"The goal is to empower the broader community to benefit from clever parallel algorithms, highly tuned implementations and specialized high performance computing hardware, without requiring expertise in any of these," says a summary of the research project.
Aluru said the resulting software libraries will be fully open-sourced. Researchers will be free to use the libraries while developing, editing and modifying them as needed.
"We're hoping this approach can be the most cost-effective and fastest way to gain adoption in the research community," Aluru said. "We want to get everybody up to speed using high performance computing."
###
Contacts:
Srinivas Aluru, Electrical and Computer Engineering, 515-294-3539, aluru@iastate.edu
Mike Krapfl, News Service, 515-294-4917, mkrapfl@iastate.edu
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/isu-isr100312.php
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Source: http://feedproxy.google.com/~r/Techcrunch/~3/mHFhrHQ9fP8/
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Source: http://news.yahoo.com/zuckerberg-says-majority-mobile-facebook-users-aren-t-230534339.html
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FILE - This Sept. 21, 2012 file photo shows Libyan civilians celebrate the raiding of Ansar al-Shariah Brigades compound, after hundreds of Libyans, Libyan Military, and Police raided the Brigades base, in Benghazi, Libya. Small teams of U.S. special operations forces arrived at American embassies throughout North Africa to set up a new counterterrorist network months before militants killed the U.S. ambassador in Libya. But officials say the network was too new to stop the Benghazi attack. (AP Photo/Mohammad Hannon, File )
FILE - This Sept. 21, 2012 file photo shows Libyan civilians celebrate the raiding of Ansar al-Shariah Brigades compound, after hundreds of Libyans, Libyan Military, and Police raided the Brigades base, in Benghazi, Libya. Small teams of U.S. special operations forces arrived at American embassies throughout North Africa to set up a new counterterrorist network months before militants killed the U.S. ambassador in Libya. But officials say the network was too new to stop the Benghazi attack. (AP Photo/Mohammad Hannon, File )
FILE - In this Oct. 28, 2008 file photo, taken with a night vision scope, U.S. Special Operations forces are seen during a joint operation with Afghan National Army soldiers targeting insurgents operating in Afghanistan's Farah province. Small teams of U.S. special operations forces arrived at American embassies throughout North Africa to set up a new counterterrorist network months before militants killed the U.S. ambassador in Libya. But officials say the network was too new to stop the Benghazi attack. (AP Photo/Maya Alleruzzo, File)
FILE - In this Sept. 14, 2012 file photo, Libyan followers of Ansar al-Shariah Brigades burn the U.S. flag during a protest in front of the Tibesti Hotel, in Benghazi, Libya. Small teams of U.S. special operations forces arrived at American embassies throughout North Africa to set up a new counterterrorist network months before militants killed the U.S. ambassador in Libya. But officials say the network was too new to stop the Benghazi attack. (AP Photo / Mohammad Hannon, File)
FILE -In this June 27, 2012 file photo, House Oversight and Government Reform Committee Chairman Rep. Darrell Issa, R-Calif. speaks on Capitol Hill in Washington. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/J. Scott Applewhite, File)
FILE - In this April 11, 2011 file photo, Ambassador Chris Stevens is seen in Benghazi, Libya. Leaders of a House committee said Tuesday that U.S. diplomats in Libya made repeated requests for increased security for the consulate in Benghazi and were turned down by officials in Washington. In a letter to Secretary of State Hillary Rodham Clinton, Chairman Darrell Issa and Rep. Jason Chaffetz said their information came from "individuals with direct knowledge of events in Libya." (AP Photo/Ben Curtis, File)
WASHINGTON (AP) ? Small teams of special operations forces arrived at American embassies throughout North Africa in the months before militants launched the fiery attack that killed the U.S. ambassador in Libya. The soldiers' mission: Set up a network that could quickly strike a terrorist target or rescue a hostage.
The White House signed off a year ago on the plan to build the new military counterterror task force in the region, and the advance teams have been there for six months, according to three U.S. counterterror officials and a former intelligence official. All spoke only on condition of anonymity because they were not authorized to discuss the strategy publicly.
The effort indicates that the administration has been worried for some time about a growing threat posed by al-Qaida and its offshoots in North Africa. But officials say the military organization was too new to respond to the attack in Benghazi, where the administration now believes armed al-Qaida-linked militants surrounded the lightly guarded U.S. compound, set it on fire and killed Ambassador Chris Stevens and three other Americans.
Republicans have questioned whether the Obama administration has been hiding key information or hasn't known what happened in the immediate aftermath of the attack. They are using those questions in the final weeks before the U.S. elections as an opportunity to assail President Barack Obama on foreign policy, an area where he has held clear leads in opinion polls since the killing of Osama bin Laden in 2011.
On Tuesday, leaders of a congressional committee said requests for added security at the consulate in Benghazi were repeatedly denied. Secretary of State Hillary Rodham Clinton has said that security was increased for the anniversary of Sept. 11 and was adequate.
As of early September, the special operations teams still consisted only of liaison officers who were assigned to establish relationships with local governments and U.S. officials in the region. Only limited counterterrorism operations have been conducted in Africa so far.
The White House, the CIA and U.S. Africa Command all declined to comment.
"There are no plans at this stage for unilateral U.S. military operations" in the region, Pentagon spokesman George Little said Tuesday, adding that the focus was on helping African countries build their own forces.
For the Special Operations Command, spokesman Col. Tim Nye would not discuss "the missions and or locations of its counterterrorist forces" except to say that special operations troops are in 75 countries daily conducting missions.
The go-slow approach with the unit run by Delta Force ? the Army's top clandestine counterterrorist unit ? is an effort by the White House to counter criticism from some U.S. lawmakers, human rights activists and others that the anti-terror fight is shifting largely to a secret war using special operations raids and drone strikes, with little public accountability. The administration has been taking its time when setting up new covert operations to get buy-in from all players who might be affected, such as the ambassadors, the CIA station chiefs, regional U.S. military commanders and local leaders.
Eventually, the Delta Force group is to form the backbone of a military task force responsible for combating al-Qaida and other terrorist groups across the region with an arsenal that includes drones. But first, it will work to win acceptance by helping North African nations build their own special operations and counterterror units.
And nothing precludes the administration from using other military or intelligence units to retaliate against the perpetrators of the Sept. 11 consulate attack in Benghazi.
But some congressional leaders say the administration is not reacting quickly enough.
"Clearly, they haven't moved fast enough to battle the threat," said House Intelligence Committee Chairman Mike Rogers, R-Mich.
While Rogers would not comment on the special operations counterterrorism network, he said, "You actually have to hunt them (terrorists) down. No swift action, and we will be the recipient of something equally bad happening to another diplomat."
The Obama administration has been concerned about the growing power and influence of al-Qaida offshoots in Yemen, Somalia, Iraq and North Africa. Only the Yemeni branch has tried to attack American territory directly so far, with a series of thwarted bomb plots aimed at U.S.-bound aircraft. A Navy SEAL task force set up in 2009 has used a combination of raids and drone strikes to fight militants in Yemen and Somalia, working together with the CIA and local forces.
The new task force would work in much the same way to combat al-Qaida's North African affiliates, which are growing in numbers and are awash in weapons from post-revolutionary Libya's looted stockpiles. They are well-funded by a criminal network trafficking in drugs and hostages.
Al-Qaida in the Islamic Maghreb or AQIM, and Nigerian-based extremist sect Boko Haram are arguably the two largest and most dangerous affiliates. U.S. officials believe AQIM may have helped the local Libyan militant group Ansar al-Shariah carry out the Benghazi attack, and Boko Haram has killed more than 240 people in an anti-Christian, anti-government campaign of assassinations and bombings this year alone. Both have morphed in recent years from extremist rebel groups that challenge their home governments into terrorist groups that use violence to try to impose extreme Islamic rule on any territory they can seize across Africa.
The governments of Libya and Niger have already asked for U.S. assistance to build their own special operations capability to help combat such al-Qaida-related groups, and Nigeria has requested help to control its porous border to stop militant trafficking, according to two U.S. officials. They, too, spoke only on condition of anonymity.
Mali has asked for international assistance to win back control of its northern region from al-Qaida groups including AQIM and Boko Haram, opening the possibility of a return of U.S. special operations forces there. A U.S. training unit was pulled out of the country after a March coup that gave the militants the chaos they needed to seize the northern territory.
The top State Department official for African affairs said Tuesday that the militants in Mali "must be dealt with through security and military means."
"But any military action up there must indeed be well planned, well organized, well resourced and well thought through," said Johnnie Carson, the U.S. assistant secretary of state for African affairs. "And it must, in fact, be agreed upon by those who are going to be most affected by it."
U.S. Africa Command chief Gen. Carter Ham said "a military component" would be a part of an overall solution in northern Mali, but he ruled out an overt U.S. military presence, speaking to reporters during a visit to Algeria over the weekend.
Asked about the attack in Benghazi, Ham said it's the host country's responsibility to protect diplomatic missions on its territory.
___
Associated Press writers Aomar Ouali in Algiers and Krista Larson in Dakar contributed to this report.
___
Dozier can be followed on Twitter (at)kimberlydozier.
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As Georgia's President Mikheil Saakashvili conceded defeat Tuesday, Russia's?Dmitry Medvedev expressed hopes for improved relations between the two countries. The U.S. State Department also views Saakashvili's concession in a positive light.
By Margarita Antidze and Steve Gutterman,?Reuters / October 2, 2012
EnlargeGeorgia's President Mikheil Saakashvili on Tuesday conceded?defeat?in parliamentary elections to a coalition led by a tycoon promising to ease tensions with?Moscow, four years after the staunch U.S. ally lost a war with?Russia.
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Russian Prime Minister?Dmitry Medvedev, who has long been openly hostile to Saakashvili, welcomed the opposition victory as opening the way for "more constructive and responsible forces" to enter the?Georgian parliament.
Saakashvili's acceptance that his ruling party will go into opposition to?Bidzina Ivanishvili's Georgian Dream increased the chances of the country's first peaceful transfer of power between rival parties since the?Soviet Union?collapsed in 1991.
Although it strengthens?Georgia's democratic credentials, it could lead to an uneasy cohabitation between Ivanishvili, who is likely to become prime minister, and Saakashvili, who does not step down as president until next year.
Instability in the country would worry the West because it is a conduit for Caspian Sea energy supplies to?Europe?and has a strategic location on the?Black Sea?between former Soviet master?Russia?and Iran,?Turkey?and?central Asia.
Tonino Picula, who led a team of international observers monitoring the vote, endorsed the conduct of the elections.
"Despite a very polarising campaign that included harsh rhetoric and shortcomings, the Georgian people have freely expressed their will at the ballot box," he said in a statement.
Medvedev, who was president and commander-in-chief when?Georgia fought its disastrous war with?Russia?in 2008, expressed hopes that the result would improve the relationship between the countries.
"We can only welcome this as it probably means that more constructive and responsible forces will appear in parliament," Russian news agencies quoted him as saying.
Russia?has had no diplomatic relations with?Georgia since the five-day war, and both Medvedev and President?Vladimir Putin?have refused to have any personal contacts with Saakashvili, whom they depict as a dangerously aggressive hothead.
The agencies said Medvedev was speaking in his capacity as leader of the?United Russia party, and Putin has yet to comment.
The U.S. State Department congratulated Saakashvili for "graciously conceding" and said it sent a good signal.
Georgian Dream supporters celebrated their victory in the capital on Monday in scenes reminiscent of the euphoria of the 2003 Rose Revolution that propelled Saakashvili to power.
Motorists were again driving through?Tbilisi?on Tuesday evening with flags flying and horns sounding.
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One of the cooler features of the Galaxy Note 2 is its ability run multiple apps in split-screen mode. The feature, known as multi-view, wasn't ready for prime time at IFA, but was showcased a few days back in an official Samsung preview video a few days ago.
However, many new Galaxy Note 2 owners in Europe have noticed that the feature isn't available on their handsets. Normally, it can be activated by long-pressing the back key, however on certain devices -- including ours -- this isn't working. According to numerous forum reports, the cause is an older firmware version on these devices. So if your international Note 2 comes with version N7100XXALIE, you'll find multi-window is unavailable. If you're on the newer N7100XXALIH, the feature should be fully unlocked. You can check your software version by heading to Settings > About device.
The reason for the omission isn't clear, though it's likely the manufacturer will update those phones stuck on the earlier firmware at some point in the near future. In the meantime, we've reached out to Samsung for comment, and will update this post with any info they provide.
Source: http://feedproxy.google.com/~r/androidcentral/~3/MiDM7Ulifxw/story01.htm
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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
A new type of antibiotic can effectively treat an antibiotic-resistant infection by disarming instead of killing the bacteria that cause it. Researchers report their findings in the October 2 issue of mBio, the online open-access journal of the American Society for Microbiology.
"Traditionally, people have tried to find antibiotics that rapidly kill bacteria. But we found a new class of antibiotics which has no ability to kill Acinetobacter that can still protect, not by killing the bug, but by completely preventing it from turning on host inflammation," says Brad Spellberg of the UCLA Medical Center and David Geffen School of Medicine, a researcher on the study.
New drugs are badly needed for treating infections with the bacterium Acinetobacter baumannii, a pathogen that most often strikes hospital patients and immune- compromised individuals through open wounds, breathing tubes, or catheters. The bacterium can cause potentially lethal bloodstream infections. Strains of A. baumannii have acquired resistance to a wide range of antibiotics, and some are resistant to every FDA-approved antibiotic, making them untreatable.
Spelling and his colleagues found that in laboratory mice it was possible to mitigate the potentially lethal effects of the bacterium by blocking one of its toxic products rather than killing it.
"We found that strains that caused the rapidly lethal infections shed lipopolysaccharide [also called LPS or endotoxin] while growing. The more endotoxin shed, the more virulent the strain was," says Spellberg. This pinpointed a new therapy target for the researchers: the endotoxin these bacteria shed in the body.
Blocking the synthesis ofthe endotoxin with a small molecule called LpxC-1 prevented infected mice from getting sick. Unlike traditional antibiotics, Spellberg says, LpxC-1 doesn't kill the bacteria, it just shuts down the manufacture of the endotoxin and stops the body from mounting the inflammatory immune response to it that is the actual cause of death in seriously ill patients.
Spellberg says this is a direction few researchers have taken when exploring ways to treat infections but that it could make the difference in finding an effective drug. The results also highlight how important it is to find new, physiologically relevant ways of screening potential antibiotics for pathogens with a high degree of resistance, write the authors. Molecules like LpxC-1 that inhibit rather than kill bacteria wouldn't pass muster with traditional antibiotic screens that are based on killing effectiveness.
Liise-anne Pirofski of the Albert Einstein College of Medicine and a reviewer of the study for mBio says neutralizing virulence factors is showing a lot of promise as an alternative route for treating infections. "There's a growing movement in infectious disease therapy to control the host inflammation response in treatment rather than just 'murdering' the organism," says Pirofski. "This is a very elegant and important validation that this approach can work at least in mice."
###
mBio is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mBio.asm.org.
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
A new type of antibiotic can effectively treat an antibiotic-resistant infection by disarming instead of killing the bacteria that cause it. Researchers report their findings in the October 2 issue of mBio, the online open-access journal of the American Society for Microbiology.
"Traditionally, people have tried to find antibiotics that rapidly kill bacteria. But we found a new class of antibiotics which has no ability to kill Acinetobacter that can still protect, not by killing the bug, but by completely preventing it from turning on host inflammation," says Brad Spellberg of the UCLA Medical Center and David Geffen School of Medicine, a researcher on the study.
New drugs are badly needed for treating infections with the bacterium Acinetobacter baumannii, a pathogen that most often strikes hospital patients and immune- compromised individuals through open wounds, breathing tubes, or catheters. The bacterium can cause potentially lethal bloodstream infections. Strains of A. baumannii have acquired resistance to a wide range of antibiotics, and some are resistant to every FDA-approved antibiotic, making them untreatable.
Spelling and his colleagues found that in laboratory mice it was possible to mitigate the potentially lethal effects of the bacterium by blocking one of its toxic products rather than killing it.
"We found that strains that caused the rapidly lethal infections shed lipopolysaccharide [also called LPS or endotoxin] while growing. The more endotoxin shed, the more virulent the strain was," says Spellberg. This pinpointed a new therapy target for the researchers: the endotoxin these bacteria shed in the body.
Blocking the synthesis ofthe endotoxin with a small molecule called LpxC-1 prevented infected mice from getting sick. Unlike traditional antibiotics, Spellberg says, LpxC-1 doesn't kill the bacteria, it just shuts down the manufacture of the endotoxin and stops the body from mounting the inflammatory immune response to it that is the actual cause of death in seriously ill patients.
Spellberg says this is a direction few researchers have taken when exploring ways to treat infections but that it could make the difference in finding an effective drug. The results also highlight how important it is to find new, physiologically relevant ways of screening potential antibiotics for pathogens with a high degree of resistance, write the authors. Molecules like LpxC-1 that inhibit rather than kill bacteria wouldn't pass muster with traditional antibiotic screens that are based on killing effectiveness.
Liise-anne Pirofski of the Albert Einstein College of Medicine and a reviewer of the study for mBio says neutralizing virulence factors is showing a lot of promise as an alternative route for treating infections. "There's a growing movement in infectious disease therapy to control the host inflammation response in treatment rather than just 'murdering' the organism," says Pirofski. "This is a very elegant and important validation that this approach can work at least in mice."
###
mBio is an open access online journal published by the American Society for Microbiology to make microbiology research broadly accessible. The focus of the journal is on rapid publication of cutting-edge research spanning the entire spectrum of microbiology and related fields. It can be found online at http://mBio.asm.org.
The American Society for Microbiology is the largest single life science society, composed of over 39,000 scientists and health professionals. ASM's mission is to advance the microbiological sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide.
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/asfm-nac092812.php
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Quote:
Originally Posted by URmysunshine4 If you have had a child for a year hasn't that child developed a bond with FP & isn't a year enough time for family to come forward? |
I have heard cases where distant "kin" have come out of the woodwork even after 18 months for a newborn. Often times it may be the first that they have heard of the child. In one case, the "kin" had never even met the bio mom. She was a cousin three times removed but she wanted a baby and may have gotten that baby, I never heard the final outcome as the FPs retained an attorney to fight it.
As long as the agency can add that placement to the RU bucket, that seems to be all that matters.
OP, I understand a bit. Chubbs bio mom didn't want to do a goodbye visit in jail. We agreed to do one post finalization but she screwed up and is gone for a year now. It is really sad to me. She has seen pictures but not seen him since she abandoned him in the hospital.
Source: http://forums.adoption.com/foster-parent-support/408354-she-doesnt-get-say-goodbye.html
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ScienceDaily (Oct. 1, 2012) ? Water does not forget, says Prof. Boris Koch, a chemist at the Alfred Wegener Institute for Polar and Marine Research in the Helmholtz Association. Irrespective of what happens in the sea: whether the sun shines, algae bloom or a school of dolphins swims through a marine area -- everything and everyone leaves biomolecular tracks. With the help of a combination of new techniques, Boris Koch and colleagues can now identify and retrace some of these.
In a special volume of the open access journal Biogeosciences, these scientists report on how these analyses work and which events in the sea have so far been uncovered by researchers.
Ponds, peat holes and roadside ditches full of stagnant rainwater were previously of no interest to the chemist Boris Koch. "Then I thought: everyone knows this brown sludge; what could be interesting about it? Today we are working with these very substances that colour the water in roadside ditches brown -- or expressed more precisely, with dissolved organic matter which not only occurs in ponds, but of course also in oceans," says Boris Koch, who initiated the research project and is co-editor of the special volume.
It is true that the concentration of these so-called biomolecules per litre of water is lower in oceans than in roadside ditches. However, if we were to tip all of the seawater in the world through a biomolecular porous sieve and convert all the components contained to units of carbon, the relationship would look completely different. It is estimated that the sieve would contain around 25 billion tonnes of stored carbon. This originates primarily from the remains of dead marine organisms and also from the biomass of living whales, fish, algae, bacteria, sea grass and other marine residents. On the other hand, some 662 billion tonnes of dissolved organic carbon would pile up under the sieve, consisting of ten thousands of various substances.
All of these substances aroused Boris Koch's curiosity: "Our work with dissolved organic matter is accompanied by two fundamental difficulties: firstly, to this day we do not know how much organic material reaches the sea or is produced there and why not everything is biodegraded. Secondly, the concentration of individual dissolved biomolecules is so low that we must consistently enrich our water samples so as to be able to study the dissolved organic matter they contain in an ultra-high resolution mass spectrometer at the Helmholtz Zentrum M?nchen," explains Koch, who is a co-operative professor at the Alfred Wegener Institute and Bremerhaven University and who lectures on marine chemistry.
With the help of this mass spectrometer at the Helmholtz Zentrum M?nchen, the German Research Centre for Environmental Health, the team of scientists working with Boris Koch has for the first time succeeded in identifying thousands of individual components in the dissolved organic matter (DOM) in the course of a single measurement. "The device gives us the chemical formula of each molecule and specifies how much carbon, oxygen, hydrogen or nitrogen it contains. We need this information to find out where the individual molecule might have originated from," Boris Koch explains.
At the end of the analysis in the mass spectrometer a kind of chemical fingerprint is produced which, in the course of statistical calculation, permits concrete conclusions to be made about the water in which the dissolved organic matter once swam in. "We are just beginning our studies. However, it would appear that, using this method, we have discovered a new way of exploiting the water's chemical memory," says Boris Koch. For example, scientists can say how old the dissolved matter is, whether it was exposed to strong sunlight along its path through the oceans or which bacteria and types of plankton probably once swam in the same body of water.
"We can even trace which share of the DOM leaves its tracks in the atmosphere. Foam and waves can transport DOM into the air where it has a considerable influence on climate," adds Dr. Philippe Schmitt-Kopplin from the Institute of Ecological Chemistry at Helmholtz Zentrum M?nchen. After all, the most important questions about DOM arise from climate research. Boris Koch: "The dissolved organic matter in the ocean is one of the largest active carbon reservoirs on earth. Previously climate research paid little consideration to its storage capacity, despite the fact that it binds carbon dioxide for periods of 3000 years or more -- the average age of our sample material."
The question for scientists at the Alfred Wegener Institute is now to close these gaps in knowledge and to find out more about the role of the DOM in the global carbon cycle. The chemical analysis process could also be used in other sub-disciplines of marine research: "Oceanographers could always draw on the DOM finger print when it is not possible to distinguish water masses solely on the basis of temperature and salt content readings. Furthermore, during one of the next expeditions with the research vessel Polarstern, together with biologists we plan to examine whether the DOM in bodies of water along the migration routes of southern elephant seals demonstrates certain chemical commonalities. Perhaps we will find evidence that these marine mammals find their way using 'water odour'," chemist Boris Koch says.
Personally the new findings mean that he now sees every ditch in a different light. Koch: "We now know that every drop of water contains real chemical information which, thanks to new technology, we are now able to access."
Background: What is DOM?
Dissolved organic matter, or DOM, in the ocean is one of the largest active, organic carbon reservoirs on earth. The global volume of carbon stored in the DOM (662 billion tonnes) is comparable with the total volume of carbon in atmospheric carbon dioxide (currently 835 billion tonnes) and in land plants (610 billion tonnes). Moreover it exceeds the volume of carbon stored in living marine animals, plants and bacteria (some 3 billion tonnes) by a factor of 200.
The organic matter is formed from atmospheric carbon dioxide by primary producers such as plants and plankton by photosynthesis. This takes place both on land (plants) and in the sea (algae). The DOM formed is either transported to the oceans via rivers or it is directly released in the seawater or sea ice, for example by algae and converted by microbial degradation. In flat coastal waters and the open sea, bacteria absorb take up part of the DOM as their most important source of organic energy. They decompose the material and break it down into its basic components. The carbon dioxide created in the process dissolves in the water and can thereby escape back into the atmosphere.
The other part of the freshly incorporated DOM is initially not broken down by bacteria, but rather chemically modified, and withstands the decomposition process for a period of up to 5000 years. This is an extremely unusual process from a chemical point of view because in principle the oxygen-rich water column should promote rapid microbial degradation of the organic material. The two major questions are now: why are degradation processes interrupted and why does a significant part of the atmospheric carbon remain stored in the DOM of the oceans, circulating them for a long time? In this way marine DOM acts as a buffer in the organic carbon cycle.
Despite the evident major significance of DOM, until now it has been scarcely possible to classify it in the global carbon cycle. The complex composition of the DOM represented an enormous analytical challenge. Consequently, there was insufficient information about the precise sources of the DOM, the formation and degradation processes and its binding mechanisms with minerals and heavy metals.
Reference: http://www.biogeosciences.net/special_issue95.html
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The above story is reprinted from materials provided by Helmholtz Association of German Research Centres.
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/0hfcW4Nep7Y/121001102433.htm
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In today?s time and age, where everybody is living a hectic life and running a rat race, people tend to take good care of their health. But as an old proverb goes, ?health is wealth? you should take good care of your health and everything else will follow. By keeping good health, you will be able to enjoy the things you earn more. Balanced diet and regular exercise are the keys to better health. There are various types of exercise regimes available which will keep you fit and healthy. Along with other traditional methods of exercise, a large number of people nowadays prefer getting enrolled in the boxing class because of the many benefits it offers to its students. In fact, in the last couple of years, the number of people getting enrolled in such classes has increased manifold. There are many benefits of taking these classes, the main being? building stronger and more defined arms and legs. People who are suffering from the problem of obesity can also get benefited by it as it helps in losing weight rapidly. It is a proven fact, that a single cardio session workouts helps you in burning about? 350 to 500 calories. On the top it, boxing classes also help in keeping the heart rate at 75% to 85% normal beat.
Another important benefit of getting enrolled in a good boxing class is that it teaches you various methods of self defense. It can be of great help during critical situations and you will be able to defend yourself against anti social elements. It is a great stress reliever also and according to various scientific studies, physical exercise is an effective and efficient stress reliever. Nowadays, there are many boxing schools available where you can get enrolled to learn boxing classes.
So, before getting enrolled in a particular one, you should check the kinds of boxing training which they offer, who are the trainers and what are their experience and qualification in this field, what are the equipments they use and many more such things. It will be better if you get enrolled in a boxing school which has a good name in this field and also have some years of experienced in this field. Since they have a certain reputation in this field, they will provide very good training to the students to live up to the reputation.Boxing training classes will? teach you the variations ?f the sparring jabs, power punches, defense, ?nd fitness which h?? ?ll blends ?f aerobics exercises. Y?u will l??rn the proper execution ?f the punch ?nd kick combinations for ? m?r? intensive workout th?t can h?lp ??u b?com? stronger ?nd m?re positive and confident about yourself. It will also help you to be in a good shape as it will help you in developing balance ?nd coordination th?t enables ??ur bod? t? b? stable ?nd maintain ? g??d f?rm. So, get enrolled in a good boxing class and enjoy its benefits.
Source: http://boxing.ezinemark.com/the-increasing-popularity-of-boxing-classes-7d37d3d4c031.html
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West Virginia quarterback Geno Smith (12) looks for a receiver during their NCAA college football game against Baylor in Morgantown, W.Va., Saturday, Sept. 29, 2012. (AP Photo/Christopher Jackson)
West Virginia quarterback Geno Smith (12) looks for a receiver during their NCAA college football game against Baylor in Morgantown, W.Va., Saturday, Sept. 29, 2012. (AP Photo/Christopher Jackson)
West Virginia's Stedman Bailey (3) is tackled in the endzone for a touchdown by Baylor's K.J. Morton (8) during their NCAA college football game in Morgantown, W.Va., Saturday, Sept. 29, 2012. (AP Photo/Christopher Jackson)
West Virginia's Tyler Anderson (53), right foreground, tackles Baylor's Terrance Williams (2) before the goal line during their NCAA college football game in Morgantown, W.Va., Saturday, Sept. 29, 2012. (AP Photo/Christopher Jackson)
West Virginia quarterback Geno Smith gestures to fans after their NCAA college football game against Baylor in Morgantown, W.Va., Saturday, Sept. 29, 2012. Smith threw for 656 yards and tied a Big 12 record with eight touchdown passes to lead No. 9 West Virginia to a 70-63 win over No. 25 Baylor . (AP Photo/Christopher Jackson)
West Virginia coach Dana Holgorsen discuss a call with officals during their NCAA college football game against Baylor in Morgantown, W.Va., Saturday, Sept. 29, 2012. West Virginia defeated Baylor 70-63. (AP Photo/Christopher Jackson)
MORGANTOWN, W.Va. (AP) ? No. 9 West Virginia and the Big 12, perfect together.
Geno Smith and the fast-moving, high-scoring Mountaineers proved they fit right in with their new conference, outracing No. 25 Baylor 70-63 on Saturday in the Big 12's highest-scoring game ever.
Smith tied a conference mark with eight touchdown passes and narrowly missed another one with 656 yards passing.
"It did feel like one of those classic Texas shootouts," said Smith, whose school moved over from the Big East this season. "That's kind of what the Big 12 is about."
Smith outdueled Baylor's Nick Florence, who broke Heisman Trophy-winning predecessor Robert Griffin III's school record with 581 yards. Florence threw for five TDs.
School, conference and FBS marks all got rewritten in this one.
The game also set a new record for the most points scored in a game involving a team ranked in The Associated Press poll. The previous mark of 124 was set in No. 12 Oklahoma's 82-42 win over Colorado in 1980.
How wild was it? Smith, the early Heisman front-runner, had more TD passes than incompletions (six). He finished 45 of 51 and still doesn't have an interception this season.
"Can you please tell me how you can improve on that?" West Virginia coach Dana Holgorsen said.
Maybe not on offense, but both defenses have plenty of work to do.
West Virginia amassed a school-record 807 yards and the teams combined for 1,507 yards of offense and 67 first downs. Six receivers had at least 100 yards receiving.
The Bears' Terrance Williams set a Big 12 record with 314 yards receiving. The old mark was set minutes earlier by West Virginia's Stedman Bailey, who had 303 yards and a school-record five TDs.
Williams' 8-yard scoring catch brought Baylor (3-1) within 70-63 with 3:08 left.
But Dustin Garrison ran for 17 yards on third down and the Mountaineers ran out the clock to snap Baylor's nine-game winning streak, the second-longest in the nation.
"We expect to score that many points a game," Florence said. "But the goal is to score more than our opponent and we came up a little short today."
The combined 19 touchdowns tied an FBS mark, last reached when Navy beat North Texas 74-62 in 2007. That matchup set the FBS record for most points in a regulation game at 136.
Baylor, meanwhile, tied an FBS mark for the most points scored by a losing team.
Among the other records, Smith set school single-game marks for completions, yards and touchdown passes.
Bailey and Tavon Austin became the first FBS teammates with 200 yards receiving since 2007.
Going back to the Orange Bowl, West Virginia has scored 10 touchdowns three times in its last five games.
"Statistically, it's my best game ever," Smith said. "But I think it's more about the team, and I think it just lets us know that we're going to have to battle it out every week against some really tough teams in the Big 12.
"I could care less about a Heisman Trophy. The big thing for us what that we won the game today. We're on a mission, and we want to win them all."
West Virginia went ahead for good early in the third quarter, but Baylor almost always had an answer.
Austin made long touchdown grabs three minutes apart while Baylor punted and missed a long field goal. Smith stayed in a groove, throwing three passes of 45 yards or more in the third quarter alone. His 47-yarder to Bailey set up Andrew Buie's second short TD run for a 56-35 lead.
The way this game was going, though, no cushion was safe.
Williams caught a 37-yard scoring pass from Florence and, after Baylor's defense forced a rare punt, Florence's sneak brought the Bears within 56-49, and there was still 14:14 left.
But Bailey scored on TD grabs of 87 and 39 yards after that.
"We fought hard," said Baylor coach Art Briles. "But we didn't respond well enough to win the game."
Holgorsen talked at length about how impatient he got watching Maryland's offense run the clock down before each snap last week.
There was no chance of a slowdown from Baylor.
The teams scored on 10 of their final 13 possessions of the first half. Seven of those drives lasted under two minutes.
Smith, whose passing yardage total was 5 yards shy of the Big 12 mark, completed a school-record 14 straight passes at one point. After a dropped pass, Smith completed 12 more in a row.
Smith's fourth TD pass came with 29 seconds left until halftime, but that was more than enough time for Florence. On second down he threw down the left sideline to Lanear Sampson, who juked two defenders and went 67 yards untouched to tie the score at 35-35.
The Mountaineers now must hope they can generate points on the road when they head to No. 12 Texas and Texas Tech over the next two weeks.
"Not every Big 12 game is like this," Holgorsen said.
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